Take the Pennyrile Parkway South toward Hopkinsville to Exit #11. Northern Ohio River Region — The counties that are part of the Cincinnati metropolitan area are more commonly known as Northern Kentucky. There are 11 ways to get from Kentucky to New Orleans by plane, bus, night bus, train or car. A car with an average MPG will needs 8.33 gallons of gas to get the route between these points. Owensboro is the fourth largest city by population in the U.S. state of Kentucky. The population was 4,014 at the 2000 census. There are 143.35 miles from Owensboro to Lexington in east direction and 184 miles (296.12 kilometers) by car, following the I-64 E route.. Owensboro and Lexington are 2 hours 59 mins far apart, if you drive non-stop.. There are 2 ways to get from Lexington to Owensboro by bus or car. From Lexington, KY: We are located approximately 245 miles from Lexington. See distance to other cities from Owensboro – Kentucky – USA measured in kilometers (km), miles and nautical miles and their local time. 5 major cities are near Owensboro; Bowling Green being the closest is 70.1 miles or 112.8 kilometers away. Now let's assume you have a private jet and you can fly in the fastest possible straight line between Owensboro, Kentucky and Lexington, Kentucky. The post office was opened on April 1, 1806 by John Field, who also ran a local store. Please note that this information about the bus from Lexington to Owensboro is approximate. How far is it from Owensboro, KY to Lexington, KY? This location is 88.15 miles away from Lexington, KY and Owensboro, KY and it would take approximately 1 hour 29 mins to reach the halfway point from both locations. Kentucky is far from any ocean beaches, with the closest ocean being the Atlantic. The closest town to the halfway point is Floyds Knobs, IN, situated 86.91 miles from Lexington, KY and 96.87 miles from Owensboro, KY. The halfway point is Floyds Knobs, IN. Richmond is Kentucky's seventh-largest city (after Louisville, Lexington, Bowling Green, Owensboro, Covington, and Hopkinsville) and the second largest city in the Bluegrass region (after Lexington). MAPS Your journey on the Kentucky Bourbon Trail® begins and ends wherever you'd like. The driving distance between Lexington, KY and Owensboro, KY is approximately 180 miles. Flight distance is approximately 143 miles (231 km) and flight time from Lexington, KY to Owensboro, KY is 17 minutes.Don't forget to check out our "Gas cost calculator" option. How far is it to drive from Lexington-Fayette, Kentucky to Owensboro, Kentucky? Lexington is the second-largest city in Kentucky and the 60th-largest city in the United States. Now let's assume you have a private jet and you can fly in the fastest possible straight line between Owensboro, Kentucky and Lexington, Kentucky. Merge onto I-65 South to the Western Kentucky Parkway, west toward Owensboro and Paducah.